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The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and marginally soluble in alcohol. The molecular weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's the next chemical construction.You can't legally import a prescription drug Unless of course you are a practitioner, a drug manufacturer, a wholesale druggist, a registered pharmacist, or maybe a resident of a foreign region though a customer in copyright.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, demanding watchful thought of the results on the parent drug, codeine, and also the active metabolite, morphine.
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Polypharmacy is a snowballing issue that goes Along with the raises in clinical knowledge and improved existence expectancy. Medicines are holding shop now us alive for for a longer time, but as we live extended We have now more medical difficulties for which we'd like medicines.
The dosage of Promethazine HCl and Codeine Phosphate Oral Resolution should not be enhanced if cough fails to reply; an unresponsive cough needs to be reevaluated in 5 days or faster for doable underlying pathology, which include foreign overall body or decreased respiratory tract sickness [see Dosage and Administration (two.3)].
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Fever reduction: Stilpane can help lower fevers accompanying the flu or other bacterial infections mainly because of the paracetamol information.
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The concomitant use of Promethazine HCl and Codeine Phosphate Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may well bring about reduced codeine stages, increased norcodeine levels, and fewer metabolism through 2D6 with resultant decreased morphine levels.
Hemodialysis is not really routinely utilised to improve the elimination of codeine or promethazine from the body.